A total of 43 alleged members and associates of the Mexican Mafia prison gang were arrested this week on multiple charges, the U.S. Attorney’s Office in the central district of California said on April 23.

The U.S. Attorney’s Office said the total includes individuals already in custody, 25 of whom were arrested in Orange County, California, on April 23. They face charges including kidnapping, extortion, fentanyl and methamphetamine trafficking, running illegal gambling businesses, and murder.

Bill Essayli, first assistant U.S. attorney, said the arrests reflected joint efforts between federal and local law enforcement and their commitment to cracking down on violent felons and organized crime.

“Gang members who murder, extort, kidnap, and traffic drugs and firearms are a menace to our communities and our way of life,” Essayli said in a statement.

The investigation also led to the seizure of 4 kilograms (8.8 pounds) of fentanyl, 54.4 kilograms (120 pounds) of methamphetamine, 0.9 kilograms (2 pounds) of heroin, 3 kilograms (6.6 pounds) of cocaine, 25 firearms, and more than $30,000 in cash, according to the office.

The U.S. Attorney’s Office said the gang sold illegal drugs in Orange County and ran illicit gambling businesses within commercial strip malls and private residences. It also collected “extortionate taxes” and used violence to safeguard those gambling businesses, the office stated.

One of the defendants, identified as Luis Cardenas, was accused of overseeing the gang’s criminal activities from his prison cell using “an encrypted messaging application on contraband cell phones” between June 2024 and April 2026. Cardenas allegedly instructed gang members to kidnap and assault those “in bad standing” with him.

Two other defendants—Matthew Kundrat and Manuel Ramos—were charged with murder that occurred at the Akua Inn, a gang-run motel in Anaheim, California, on Feb. 3, 2025. Prosecutors said the two allegedly committed the murder to be part of the Mexican Mafia and increase their standing within the gang.

“These defendants allegedly ran a ruthless criminal enterprise that murdered, kidnapped, extorted, and flooded our communities with deadly drugs,” FBI Director Kash Patel said in a statement.

“The FBI will never stop working alongside our law enforcement partners to hold these individuals accountable and protect the people of Southern California.”

Some of the defendants made their initial appearances in U.S. District Court in Santa Ana and Los Angeles on April 23, according to the U.S. Attorney’s Office.

The Mexican Mafia, also known as “La Eme,” is a U.S.-based prison gang that started in the 1950s. Federal authorities said the gang exerts “immense control” over Hispanic street gangs in Southern California, directing illegal activities from within prisons and taking a portion of the proceeds from drug trafficking, illegal gambling, and other crimes.