PORTER RANCH, Calif.—Two people were killed and two others were injured in a wrong-way crash on the Ronald Reagan (118) Freeway in Porter Ranch March 5, authorities said.

The crash on the westbound freeway, at the Tampa Avenue off-ramp, was reported at 4:25 a.m. Sunday, the California Highway Patrol reported. Authorities said a dark-colored sedan was driving eastbound in the westbound lanes and slammed into a semi-truck. The vehicle landed on the embankment of the off-ramp.

Two people were pronounced dead at the scene. Paramedics dispatched to the location at 4:30 a.m. rushed two others to regional trauma centers, according to Brian Humphrey of the Los Angeles Fire Department.

A Sigalert, issued at 4:53 a.m. closing the Tampa Avenue off-ramp, as well as the No. 3 and 4 lanes of the westbound freeway, was canceled at 11:20 a.m.

A representative from the Los Angeles County coroner’s office was called to the scene at 5:44 a.m.